Bioframe enables flexible and scalable operations on Pandas dataframes of genomic intervals.¶
A sequenced genome provides a common coordinate system for locating features of interest.¶
Image from Fantastic Genes and Where to Find Them by Maria Gallegos
Positions and intervals provide addresses for anything that can be mapped to a reference genome:
- Alignments of short sequencing reads
- Sites of genetic variation
- Individual genes and their substructual components
- Locations occupied by DNA-binding proteins in particular cell types
- And much more!
It is no wonder that positions and intervals are key fields in most genomic data files!
For example, next-generation sequencing (NGS) technologies can map all kinds of functional biomolecular information along this coordinate system.
